Blar i forfatter "Zykova, Svetlana"
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The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study
Solbu, Marit Dahl; Norvik, Jon Viljar; Storhaug, Hilde-Merete; Eriksen, Bjørn Odvar; Melsom, Toralf; Eggen, Anne Elise; Zykova, Svetlana; Kronborg, Jens; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-14)Background/Aims: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponectin, serum uric acid (SUA) and urinary biomarkers of glomerular and tubular damage (albumin-creatinine ... -
The association between infant salivary cortisol and parental presence in the neonatal intensive care unit during and after COVID-19 visitation restrictions: A cross-sectional study
Brekke, Stine Marie; Halvorsen, Silje Torp; Bjørkvoll, Julie; Thorsby, Per Medbøe; Rønnestad, Arild Erland; Zykova, Svetlana; Bakke, Liv Hanne; Dahl, Sandra Rinne; Haaland, Kirsti; Siw Helen, Westby Eger; Solberg, Marianne Trygg; Solevåg, Anne Lee (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-07)Objectives: Parent-infant interaction in the neonatal intensive care unit (NICU) promotes health and reduces infant stress. During the COVID-19 pandemic, however, NICUs restricted parent-infant interaction to reduce viral transmission. This study examined the potential relationship between pandemic visitation restrictions, parental presence and infant stress as measured by salivary cortisol. Methods: ... -
Cross-sectional analysis of nutrition and serum uric acid in two Caucasian cohorts: the AusDiab Study and the Tromsø study
Zykova, Svetlana; Storhaug, Hilde-Merete; Toft, Ingrid; Chadban, Steven; Jenssen, Trond Geir; White, Sarah L (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-14)Background: Hyperuricemia can lead to gout, and may be a risk factor for cardiovascular events, hypertension, diabetes and renal disease. There is well-known link between gout and habitual intake of meat and seafood, however the association between hyperuricemia and micro-and macro-nutrient intake has not been established. <p>Methods: We studied associations between intakes of food categories, ... -
Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men
Brovold, Henrik; Lund, Trine; Svistounov, Dmitri; Solbu, Marit Dahl; Jenssen, Trond Geir; Ytrehus, Kirsti; Zykova, Svetlana (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-19)Several epidemiological studies have pointed at serum uric acid (SUA) as an independent risk factor for mortality, diabetes, hypertension, cardiovascular and kidney disease; however, no clear pathogenic pathway is established. Uric acid (UA) crystals show pro-inflammatory properties and can thus create or contribute to the state of chronic low-grade inflammation, a widely accepted pathogenic mechanism ... -
Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry
Svistounov, Dmitri; Solbu, Marit Dahl; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Hansen, Terkel; Elgstøen, Katja Benedikte Prestø; Zykova, Svetlana (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)Purine metabolism is essential for all known living creatures, including humans in whom elevated serum concentration of purine break-down product uric acid (UA) is probably an independent risk factor for mortality, type 2 diabetes and cardiovascular events. An automated multiplex assay that measures several purine metabolites could therefore prove useful in many areas of medical, veterinary and ... -
Hepatic disposal of advanced glycation end products during maturation and aging
Svistounov, Dmitri; Oteiza, Ana; Zykova, Svetlana; Sørensen, Karen Kristine; McCourt, Peter Anthony; McLachlan, Andrew J; Mccuskey, Robert Scott; Smedsrød, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Aging is characterized by progressive loss of metabolic and biochemical functions and accumulation of metabolic by-products, including advanced glycation end products (AGEs), which are observed in several pathological conditions. A number of waste macromolecules, including AGEs are taken up from the circulation by endocytosis mainly into liver sinusoidal endothelial cells (LSECs) and Kupffer cells ... -
Low adiponectin is associated with diastolic dysfunction in women: A cross-sectional study from the Tromsø Study
Norvik, Jon Viljar; Schirmer, Henrik; Ytrehus, Kirsti; Jenssen, Trond Geir; Zykova, Svetlana; Eggen, Anne Elise; Eriksen, Bjørn Odvar; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-14)Background: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. <br>Methods: We conducted a cross-sectional ... -
Macrophage stimulating agent soluble yeast β-1,3/1,6-glucan as a topical treatment of diabetic foot and leg ulcers: A randomized, double blind, placebo-controlled phase II study
Zykova, Svetlana; Balandina, K; Vorokhobina, NV; Kuznetsova, A; Engstad, R; Zykova, TA (Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study
Norvik, Jon Viljar; Storhaug, Hilde-Merete; Ytrehus, Kirsti; Jenssen, Trond Geir; Zykova, Svetlana; Eriksen, Bjørn Odvar; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)Background: Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS). In a prospective cohort study, we assessed whether baseline and longitudinal change in UA were risk factors for development of MetS and its individual components. <br> Methods: We included 3087 women and 2996 men who had UA measured in the population based Tromsø Study 1994–95. The participants ... -
Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis
Zykova, Svetlana; Tveita, Anders Aune; Rekvik, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study
Storhaug, Hilde-Merete; Norvik, Jon Viljar; Toft, Ingrid; Eriksen, Bjørn Odvar; Løchen, Maja-Lisa; Zykova, Svetlana; Solbu, Marit Dahl; White, Sarah; Chadban, S; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional ...